Cartilage

Authors: John P. Caron, Jeff C. Gandy, Michelle Schmidt, Joseph G. Hauptman and Lorraine M. Sordillo
Journal: Veterinary Surgery

Objective

To compare the effects of triamcinolone acetonide (TA) and methylprednisolone acetate (MPA) on expression of selected chondrocyte genes in recombinant equine interleukin-1β (reIL-1β) stimulated articular cartilage explants.

Design

In vitro experiment.

Animals

Horses (n = 6).

Procedures

Category: Cartilage - Equine
Authors: Woong Kim, PhD; Brian H. McArdle, PhD; Chris E. Kawcak, DVM, PhD; C. Wayne McIlwraith, BVSc, PhD; Elwyn C. Firth, BVSc, PhD; Neil D. Broom, PhD
Journal: American Journal of Veterinary Research

Objective—To investigate histomorphometric changes in the cartilage and subchondral bone of the third carpal bone associated with conditioning exercise in young Thoroughbreds.

Animals—Nine 18-month-old Thoroughbreds.

Category: Cartilage - Equine
Authors: Francesca Beccati, Heather J. Chalmers, Sara Dante, Eleonora Lotto and Marco Pepe
Journal: Veterinary Radiology and Ultrasound

Osteochondrosis lesions commonly occur on the femoral trochlear ridges in horses and radiography and ultrasonography are routinely used to diagnose these lesions. However, poor correlation has been found between radiographic and arthroscopic findings of affected trochlear ridges. Interobserver agreement for ultrasonographic diagnoses and correlation between ultrasonographic and arthroscopic findings have not been previously described.

Authors: Ann Carstens, Robert M. Kirberger, Leif E. Dahlberg, Leon Prozesky, Lizelle Fletcher and Eveliina Lammentausta
Journal: Veterinary Radiology and Ultrasound

The purpose of this study was to determine whether delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and T2 mapping are accurate techniques for measuring cartilage thickness in the metacarpus3/metatarsus3 (Mc3/Mt3) of Thoroughbred racehorses. Twenty-four Mc3/Mt3 cadaver specimens were acquired from six healthy racehorses.

Category: Cartilage - Equine - Imaging - MRI
Authors: Perrine Piat, Hélène Richard, Guy Beauchamp and Sheila Laverty
Journal: Veterinary Surgery

Objective

To assess the effects of an intra-articular (IA) lidocaine or bupivacaine injection on synovial fluid (SF) biomarkers of cartilage metabolism.
Study Design

Experimental.
Animals

Horses (n = 6).
Methods

Authors: Katja F. Duesterdieck-Zellmer, Dr med vet, PhD; Nellie Driscoll, DVM; Jesse F. Ott, BS
Journal: American Journal of Veterinary Research

Objective—To determine concentration-dependent effects of tiludronate on cartilage explants incubated with or without recombinant equine interleukin-1β (rEq IL-1).

Sample—Articular cartilage explants from the femorotibial joints of 3 young adult horses.

Category: Cartilage - Equine
Authors: K. F. ORTVED, A. J. NIXON, H. O. MOHAMMED and L. A. FORTIER
Journal: Equine Veterinary Journal

Reasons for performing study: To evaluate the long-term clinical outcome after allogeneic chondrocyte and insulin-like growth factor-I (IGF-I) grafting of subchondral cystic lesions (SCLs) of the femoral condyle in horses.

Objective: To test the hypothesis that chondrocyte and IGF-I grafts will improve the long-term clinical outcome in arthroscopically debrided SCLs.

Category: Cartilage - Equine
Authors: R. M. Thiede, Y. Lu, M. D. Markel
Journal: Veterinary and Comparative Orthopaedics and Traumatology (VCOT)

The purpose of this article is to provide a broad review of the literature related to the treatment of cartilage defects and degenerated cartilage in animals with some inferences to the treatment in humans. Methods range from the insertion of osteochondral tissue or cells to the application of radio frequency or insertion of scaffolds and growth factors alone or in combination. Debridement, microfracture, radio frequency, and chondrocyte implantation are all methods normally utilized when treating smaller articular cartilage defects.

Category: Cartilage
Authors: Helen E. McCarthy, Jennifer J. Bara, Karen Brakspear, Sim K. Singhrao, Charles W. Archer
Journal: The Veterinary Journal

A chondrocyte progenitor population isolated from the surface zone of articular cartilage presents a promising cell source for cell-based cartilage repair. In this study, equine articular cartilage progenitor cells (ACPCs) and equine bone marrow-derived stromal cells (BMSCs) were compared as potential cell sources for repair.

Category: Cartilage - Equine - Stem cells
Authors: I. M. WRIGHT, G. J. MINSHALL
Journal: Equine Veterinary Journal

Reasons for performing study: Although a well recognised clinical entity, only small numbers of osteochondromata on the caudal distal radius have previously been published and its occurrence in young racing Thoroughbreds has not previously been reported. Identification and management of associated lesions in the deep digital flexor tendon have received scant attention in the literature.