Cartilage

Authors: Anna J Schreiner, James P Stannard, Aaron M Stoker, Chantelle C Bozynski, Keiichi Kuroki, Cristi R Cook, James L Cook

Osteochondral allograft (OCA) transplantation can functionally restore large articular defects in the knee. Bipolar OCA transplantations for partial and whole joint resurfacing often have less favorable results than single-surface transplants.

Category: Cartilage - Stifle
Authors: Abdul Wahed Kajabi, Victor Casula, Jaakko K Sarin, Juuso H Ketola, Olli Nykänen, Nikae C R Te Moller, Irina A D Mancini, Jetze Visser, Harold Brommer, P René van Weeren, Jos Malda, Juha Töyräs

Chondral lesions lead to degenerative changes in the surrounding cartilage tissue, increasing the risk of developing post-traumatic osteoarthritis (PTOA). This study aimed to investigate the feasibility of quantitative magnetic resonance imaging (qMRI) for evaluation of articular cartilage in PTOA.

Category: Cartilage - Imaging
Authors: Anna J Schreiner, James P Stannard, Cristi R Cook, Chantelle C Bozynski, Keiichi Kuroki, Aaron M Stoker, Patrick A Smith, James L Cook

Meniscal allograft transplantation (MAT) can be a safe, effective treatment for meniscal deficiency resulting in knee dysfunction, leading to osteoarthritis (OA) without proper treatment with 5-year functional success rates (75%-90%). While different grafts and techniques have generally proven safe and effective, complications include shrinkage, extrusion, progression of joint pathology, and failure.

Category: Cartilage
Authors: Tetsuya Nakajo, Yukihiro Fujita, Tom Ichinohe, Takuya Maruo

Osteochondrodysplasia affects both homozygous and heterozygous Scottish Fold cats, and various treatments have been attempted to control chronic pain and improve mobility in these animals. However, to date, there is no single effective treatment that can be used to treat all cats with Scottish Fold osteochondrodysplasia (SFOCD).

Category: Cartilage
Authors: Bansal S, Miller LM, Patel JM, Meadows KD, Eby MR, Saleh KS, Martin AR, Stoeckl BD, Hast M, Elliott DM, Zgonis MH, Mauck RL

The meniscus plays a central load bearing role in the knee joint. Unfortunately, meniscus injury is common and can lead to joint degeneration and osteoarthritis. In small animal models, progressive degenerative changes occur with unloading of the meniscus via destabilization of the medial meniscus (DMM).

Category: Cartilage - Stifle
Authors: Kon E, Robinson D, Shani J, Alves A, Di Matteo B, Ashmore K, De Caro F, Dulic O, Altschuler N

PURPOSE: The aim of this study is to investigate the safety and regenerative potential of a hemicondylar aragonite-based scaffold in the reconstruction of large osteochondral lesions occupying an extensive portion of the medial femoral condyle in a goat model.

Category: Cartilage
Authors: Olive M, Boyer C, Lesoeur J, Thorin C, Weiss P, Fusellier M, Gauthier O

OBJECTIVE: To determine the ability of three implants to enhance the healing of osteochondral defects: (1) a biphasic construct composed of calcium phosphate (CaP) and chitosan/cellulosic polymer, (2) a titanium-polyurethane implant, and (3) an osteochondral autograft.

STUDY DESIGN: Experimental study.

ANIMALS: Ten adult female sheep.

Category: Cartilage
Authors: Oliver HA, Bozynski CC, Cook CR, Kuroki K, Sherman SL, Stoker AM, Cook JL.

This study characterizes outcomes associated with subchondroplasty (SCP) versus SCP enhanced with platelet-rich plasma (PRP) or bone marrow aspirate concentrate (BMC) treatment of impact-induced subchondral bone marrow lesions (BML) using a validated preclinical canine

Category: Cartilage
Authors: Schmaranzer F1, Arendt L, Liechti EF, Nuss K, von Rechenberg B, Kircher PR, Tannast M.

BACKGROUND: Biochemical MRI of hip cartilage such as delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and T2 mapping is increasingly used to judge cartilage quality in the assessment of femoroacetabular impingement (FAI).

Category: Cartilage
Authors: Chastain KS, Stoker AM, Bozynski CC, Leary EV, Cook JL.

PURPOSE: The objective of this study was to determine the responses of normal meniscus to collagenase activity. It was hypothesized that meniscal explants exposed to collagenase would significantly increase release of pro-inflammatory cytokines and degradative enzymes, in a dose-dependent manner, compared to control.

Category: Cartilage