Authors: Caleb W Grote, Matthew J Mackay, Qinghua Lu, Xiangliang Liu, Anders R Meyer, Jinxi Wang

This study aims to develop a comprehensive and easily executable histopathologic grading scheme for murine knee osteoarthritis (OA) using specific scoring criteria for both cartilage and periarticular changes, which may overcome important limitations of the existing grading systems.

Category: Osteoarthritis
Authors: Keijiro Kanno et al.

We investigated the analgesic effects of tramadol and the arthritic changes following tramadol administration in the rat hip osteoarthritis (OA) model using mono-iodoacetate (MIA).

Category: Osteoarthritis
Authors: Masataka Enomoto, Elizabeth A Baines, Simon C Roe, Denis J Marcellin-Little, B Duncan X Lascelles

Background: This study aimed to define the rate of progression of radiographic osteoarthritis (OA) of the canine hip joint and to describe factors affecting this progression.

Category: Hip - Osteoarthritis
Authors: João C Alves, Ana Santos, Patrícia Jorge, Catarina Lavrador, L Miguel Carreira

Objectives: To compare the effect of intra-articular treatment with triamcinolone hexacetonide (TH), stanozolol, hyaluronan, and a platelet concentrate in police working dogs with bilateral hip osteoarthritis (OA).

Study Design: Prospective, longitudinal, double-blinded, negative controlled study.

Sample Population: Fifty police working dogs with naturally occurring hip OA.

Authors: Nathalie Dowgray, Eithne Comerford

Practical relevance: An understanding of the process of musculoskeletal ageing - which all senior and geriatric cats will experience - is vital to maintaining the health and welfare of our ageing cat population.

Category: Osteoarthritis
Authors: Masakazu Shimada, Nichika Mizokam, Tom Ichinohe, Nobuo Kanno, Shuji Suzuki, Takuya Yogo, Yasuji Harada, Yasushi Hara

The object of this study is to evaluate the long-term outcome of hind limb weight-bearing function and progression of stifle osteoarthritis (OA) after tibial plateau leveling osteotomy (TPLO).

Groups were classified by the degree of cranial cruciate ligament (CrCL) damage and presence or absence of medial meniscus damage as macroscopically evaluated during surgery. Weight-bearing function was assessed via the peak vertical force (PVF), and OA progression was assessed via the radiographic OA score (OAS) preoperatively and 1, 3, 6, 12, 18, 24, and 36 months postoperatively.

Category: Hip - Osteoarthritis
Authors: Aulakh KS, Dongaonkar KR, Barnes K, Gines AJ, Bordelon JT, Hulse D, Aulakh HK, Liu CC

OBJECTIVE: To determine the influence of orthopedic examination on numerical rating score (NRS) and visual analog score (VAS) when scoring lameness in dogs with elbow osteoarthritis (OA) and to evaluate interobserver and intraobserver agreement in NRS and VAS on the basis of video-graph

Category: Elbow - Osteoarthritis
Authors: Casper-Taylor ME, Barr AJ, Williams S, Wilcox RK, Conaghan PG

There is controversy over whether bone or cartilage is primarily involved in osteoarthritis (OA) pathogenesis; this is important for targeting early interventions.

Authors: Atluri K, Brouillette MJ, Seol D, Khorsand B, Sander E, Salem AK, Fredericks D, Petersen E, Smith S, Fowler TP, Martin JA.

Joint stiffness due to fibrosis/capsule contracture is a seriously disabling complication of articular injury that surgical interventions often fail to completely resolve. Fibrosis/contracture is associated with the abnormal persistence of myofibroblasts, which over-produce and contract collagen matrices.

Authors: Wu X, Cai Y, Lu S, Xu K, Shi X, Yang L, Huang Z, Xu P.

BACKGROUND: Osteoarthritis (OA) is characterized by degeneration of articular cartilage. Studies have found that enhancement of autophagy, an intracellular catabolic process, may limit the pathologic progression of OA.

Category: Osteoarthritis