Authors: J C Alves, John F Innes

Objective: Osteoarthritis is the most common joint disease in companion animals. Several client-report outcome measures (CROMs) have been developed and validated to monitor patients and their response to treatment. However, estimates for minimal clinically-important differences for these CROMs in the context of osteoarthritis have not been published.

Category: Osteoarthritis
Authors: Jimmy Lattimer, Michelle Fabiani, Lori Gaschen, Karanvir Aulakh, Kimberly Selting

Osteoarthritis of the elbow joint secondary to elbow dysplasia is common in dogs. Intraarticular radionuclide injection is thought to suppress both synovitis and inflammatory pain mediators in the joint which are not directly addressed by current treatments.

Category: Osteoarthritis
Authors: John F Innes, Mark A Morton, B Duncan X Lascelles

Client-reported outcomes measures (CROMs) have been previously validated for the evaluation of canine osteoarthritis.

Category: Osteoarthritis
Authors: João C Alves, Ana Santos, Patrícia Jorge, P Lafuente

Objective: To describe the effect of a mesotherapy protocol in dogs with osteoarthritis.

Animals: 30 dogs.

Authors: Charlotte Beerts, Glenn Pauwelyn, Eva Depuydt, Yangfeng Xu, Jimmy H Saunders, Kathelijne Peremans, Jan H Spaas

Osteoarthritis (OA) is a highly prevalent condition in dogs, causing a substantial reduction in quality of life and welfare of the animals. Current disease management focusses on pain relief but does not stop the progression of the disease. Therefore, mesenchymal stem cells (MSCs) could offer a promising disease modifying alternative. However, little is known about the behavior and the mode of action of MSCs following their administration.

Category: Osteoarthritis
Authors: Anna R Tellegen et al.

Objective: Drug delivery platforms that allow for gradual drug release after intra-articular administration have become of much interest as a treatment strategy for OA. The aim of this study was to investigate the safety and efficacy of an intra-articular sustained release formulation containing celecoxib (CXB), a COX-2 selective inhibitor.

Authors: Caleb W Grote, Matthew J Mackay, Qinghua Lu, Xiangliang Liu, Anders R Meyer, Jinxi Wang

This study aims to develop a comprehensive and easily executable histopathologic grading scheme for murine knee osteoarthritis (OA) using specific scoring criteria for both cartilage and periarticular changes, which may overcome important limitations of the existing grading systems.

Category: Osteoarthritis
Authors: Keijiro Kanno et al.

We investigated the analgesic effects of tramadol and the arthritic changes following tramadol administration in the rat hip osteoarthritis (OA) model using mono-iodoacetate (MIA).

Category: Osteoarthritis
Authors: Masataka Enomoto, Elizabeth A Baines, Simon C Roe, Denis J Marcellin-Little, B Duncan X Lascelles

Background: This study aimed to define the rate of progression of radiographic osteoarthritis (OA) of the canine hip joint and to describe factors affecting this progression.

Category: Hip - Osteoarthritis
Authors: João C Alves, Ana Santos, Patrícia Jorge, Catarina Lavrador, L Miguel Carreira

Objectives: To compare the effect of intra-articular treatment with triamcinolone hexacetonide (TH), stanozolol, hyaluronan, and a platelet concentrate in police working dogs with bilateral hip osteoarthritis (OA).

Study Design: Prospective, longitudinal, double-blinded, negative controlled study.

Sample Population: Fifty police working dogs with naturally occurring hip OA.