Cartilage

Authors: S. M. HENDRIX, G. M. BAXTER, C. W. Mc ILWRAITH † ‡ , D. A. HENDRICKSON, L. R. GOODRICH, D. D. FRISBIE † and G. W. TROTTER §
Journal: Equine Veterinary Journal 2010

Reasons for performing study: Medial meniscal injuries and subchondral cystic lesions (SCL) are known to occur independently within the medial femorotibial (MFT) joint in horses. However, there are no reports of a potential clinical relationship between these 2 types of lesions.

Objectives: To: 1) document the concurrent presence or sequential development of medial meniscal and SCL of the medial femoral condyle within the MFT joint; and 2) determine the prognosis with both types of lesions.

Authors: JOHN C. JANICEK, DVM, MS, Diplomate ACVS 1 , JAMES L. COOK, DVM, PhD, Diplomate ACVS 1 , DAVID A. WILSON, DVM, MS, Diplomate ACVS 1 , and KARISSA M. KETZNER, DVM 1
Journal: Veterinary Surgery

Objective—To adapt the multiple osteochondral autograft technique for treatment of a subchondral cystic lesion (SCL) of the proximal medial trochlear ridge (MTR) of the equine talus and assess long term outcome.

Study Design—Case report.

Animals—Quarter horse stallion with SCL of the proximal MTR of the talus.

Category: Bone - Cartilage - Equine
Authors: Evita Busschers, DVM; Jeff P. Holt, BS; Dean W. Richardson, DVM
Journal: American Journal of Veterinary Research

Objective—To determine effects of interleukin (IL)-1β and glucocorticoids on total glycosaminoglycan (GAG) loss and aggrecanase-mediated matrix degradation in equine cartilage.

Sample Population—Cartilage from 24 equine cadavers free of sepsis and musculoskeletal disease.

Category: Cartilage - Equine
Authors: Orlaith B. Cleary, MVB; Troy N. Trumble, DVM, PhD; Kelly A. Merritt, BS; Murray P. Brown, DVM, MSc
Journal: American Journal of Veterinary Research

Objective—To investigate the effects of exercise and osteochondral injury on concentrations of carboxy-terminal telopeptide fragments of type II collagen (CTX-II) in synovial fluid (SF) and serum of Thoroughbred racehorses and to compare findings with radiographic and arthroscopic scores of joint injury severity.

Animals—78 Thoroughbreds with (n = 38) and without (40) osteochondral injury.

Category: Cartilage - Equine
Authors: Elysia C. Schaefer, DVM; Allison A. Stewart, MS, DVM; Sushmitha S. Durgam, BVSc; Christopher R. Byron, MS, DVM; Matthew C. Stewart, PhD, BVSc
Journal: American Journal of Veterinary Research

Objective—To determine whether the effects of a high–molecular-weight sodium hyaluronate alone or in combination with triamcinolone acetonide can mitigate chondrocyte glyocosaminoglycan (GAG) catabolism caused by interleukin (IL)-1 administration.

Sample Population—Chondrocytes collected from metacarpophalangeal joints of 10 horses euthanized for reasons unrelated to joint disease.

Category: Cartilage - Equine
Authors: Carolyne A. Tranquille, BSc; Antony S. Blunden, PhD; Sue J. Dyson, PhD; Tim D. H. Parkin, PhD; Allen E. Goodship, PhD; Rachel C. Murray, PhD
Journal: American Journal of Veterinary Research

Objective—To investigate effects of exercise on hyaline cartilage (HC), calcified cartilage (CC), and subchondral bone (SCB) thickness patterns of equine tarsi.

Sample Population—30 tarsi from cadavers of horses with known exercise history.

Category: Bone - Cartilage - Equine
Authors: Olstad, K.; Ytrehus, B.; Ekman, S.; Carlson, C.S.; Dolvik, N.I.
Journal: Equine Veterinary Journal

Reasons for performing study: It is presently unknown whether cartilage ischaemia plays any part in the pathogenesis of osteochondral fragmentation within the equine metatarso-phalangeal joint, as no detailed studies on microcirculation in the area have been reported.

Objective: To describe the developmental pattern of the blood supply to the epiphyseal growth cartilage in the metatarso-phalangeal joint of foals.

Authors: Murray P. Brown, DVM, MSc; Troy N. Trumble, DVM, PhD; Kelly A. Merritt, BS
Journal: American Journal of Veterinary Research

Objective—To investigate effects of osteochondral injury on high-mobility group box chromosomal protein 1 (HMGB-1) concentrations in synovial fluid (SF) from Thoroughbreds and to compare these results with radiographic and arthroscopic scores of severity of joint injury. Animals—40 clinically normal rested Thoroughbreds (group 1) and 45 Thoroughbreds with osteochondral injury as a result of racing. Procedures—SF was obtained from the metacarpophalangeal (MCP) joints, metatarsophalangeal (MTP) joints, middle carpal joints, and radiocarpal joints.

Category: Cartilage - Equine
Authors: Pearson, W.; Lindinger, M.
Journal: Equine Veterinary Journal

Nutraceuticals are increasingly applied to the management of equine arthritis and joint disease, particularly those based upon glucosamine and chondroitin sulphate. While the first report of using glucosamine in horses appeared more than 25 years ago, it was not until 1992 that isolated studies began to be reported. Since that time, 15 in vivo papers have been published in the equine literature, usually on products already commercially available and often seeking evidence for efficacy.

Category: Cartilage - Equine
Authors: Gläser, K.E.; Sun, Q.; Wells, M.T.; Nixon, A.J.
Journal: Equine Veterinary Journal

Reasons for performing study: No large scale equine microarray is available commercially to allow genomic and transcriptional profiling of the majority of genes that would define the genetic basis of equine disease.

Objectives: To generate a whole transcript target labelled GeneChip to interrogate the equine transcriptome and validate chip performance using RNA samples derived from organs, articular cells and normal cartilage.

Category: Cartilage - Equine