Biologics

Authors: Rousseau M1, Anderson DE, Lillich JD, Apley MD, Jensen PJ, Biris AS.
Journal: AJVR

Objective-To determine the response of cortical bone to a multicomponent and nanostructural polymeric matrix as a drug delivery system for enhancing bone healing. Animals-20 healthy adult crossbred goats.

Authors: Warnock JJ1, Spina J2, Bobe G3, Duesterdieck-Zellmer KF2, Ott J2, Baltzer WI2, Bay BK4.
Journal: Vet J

Meniscal injury is a common cause of canine lameness. Tissue engineered bioscaffolds may be a treatment option for dogs suffering frommeniscal damage. The aim of this study was to compare in vitro meniscal-like matrix formation and biomechanical properties of porcine intestinal submucosa sheets (SIS), used in canine meniscal regenerative medicine, to synoviocyte-seeded SIS bioscaffold (SSB), cultured with fetal bovine serum (SSBfbs) or chondrogenic growth factors (SSBgf).

Category: Biologics - Knee
Authors: Etchepareborde S, Barthelemy N, Brunel L, Claeys S, Balligand M.
Journal: VCOT

Objectives: to evaluate in vitro the strength of different compositions of beta-tricalcium phosphate (β-TCP) wedges in comparison with titanium foam and cages. To study the response to cyclic loading of the strongest β-TCP wedge, titanium foam and titanium cage. Methods: Compression test: Twenty-five tibiae were prepared for tibial tuberosity advancement using the modified Maquet technique.

Authors: Warnock JJ1, Spina J2, Bobe G3, Duesterdieck-Zellmer KF2, Ott J2, Baltzer WI2, Bay BK4.
Journal: Vet J

Meniscal injury is a common cause of canine lameness. Tissue engineered bioscaffolds may be a treatment option for dogs suffering frommeniscal damage. The aim of this study was to compare in vitro meniscal-like matrix formation and biomechanical properties of porcine intestinal submucosa sheets (SIS), used in canine meniscal regenerative medicine, to synoviocyte-seeded SIS bioscaffold (SSB), cultured with fetal bovine serum (SSBfbs) or chondrogenic growth factors (SSBgf).

Category: Biologics - Knee
Authors: Stewart M.
Journal: VCOT

No Abstract

Category: Biologics
Authors: Fahie MA, Ortolano GA, Guercio V, Schaffer JA, Johnston G, Au J, Hettlich BA, Phillips T, Allen MJ, Bertone AL.
Journal: JAVMA

Objective-To determine efficacy of a single intra-articular injection of an autologous platelet concentrate for treatment of osteoarthritis in dogs. Design-Randomized, controlled, 2-center clinical trial. Animals-20 client-owned dogs with osteoarthritis involving a single joint. Procedures-Dogs were randomly assigned to a treatment or control group. In all dogs, severity of lameness and pain was scored by owners with the Hudson visual analog scale and the University of Pennsylvania Canine Brief Pain Inventory, respectively, and peak vertical force (PVF) was determined with a force platform.

Authors: Franklin SP, Cook JL.
Journal: Can Vet J

This prospective, randomized, double-blinded trial compared outcomes in dogs with bilateral elbow osteoarthritis (OA) treated with hyaluronan plus methylprednisolone (HA + S) or autologous conditioned plasma (ACP(®); Arthrex). An investigator blinded to the treatments graded lameness (0-4) before and 6 months after a single injection with either HA + S or ACP. Clients were blinded to treatment and completed a validated survey before and 1, 6, 12, and 24 weeks after injection. Ten dogs (5 per group) completed all parts of the study.

Authors: Franklin SP, Cook JL.
Journal: Can Vet J

This prospective, randomized, double-blinded trial compared outcomes in dogs with bilateral elbow osteoarthritis (OA) treated with hyaluronan plus methylprednisolone (HA + S) or autologous conditioned plasma (ACP(®); Arthrex). An investigator blinded to the treatments graded lameness (0-4) before and 6 months after a single injection with either HA + S or ACP. Clients were blinded to treatment and completed a validated survey before and 1, 6, 12, and 24 weeks after injection. Ten dogs (5 per group) completed all parts of the study.

Authors: Rhouma M, de Oliveira El Warrak A, Troncy E, Beaudry F, Chorfi Y.
Journal: Can J Vet Res

There is evidence that vitamin E (VE) has anti-inflammatory and analgesic properties in human osteoarthritis (OA). This double-blinded and randomized pilot study used a broad spectrum of clinical and laboratory parameters to investigate whether such beneficial effects could be detected in a canine experimental OA model. Dogs were divided into 2 groups: control (n = 8), which received a placebo, and test group (n = 7), which received 400 IU/animal per day of VE for 55 d, starting the day after transection of the cranial cruciate ligament.

Authors: Budsberg SC, Stoker AM, Johnston SA, Liska W, Reno LR, Cook JL.
Journal: AJVR

Objective-To assess effects of in vitro meloxicam exposure on metabolism in articular chondrocytes from dogs with naturally occurring osteoarthritis Sample-Femoral head cartilage from 16 dogs undergoing total hip replacement Procedures-Articular cartilage samples were obtained. Tissue sulfated glycosaminoglycan (SGAG), collagen, and DNA concentrations were measured. Collagen, SGAG, chondroitin sulfate 846, NO, prostaglandin E2 (PGE2), and matrix metalloproteinase (MMP)-2, MMP-3, MMP-9, and MMP-13 concentrations in culture medium were analyzed.